At the same time that social justice concerns are on the rise on college campuses, empathy levels among US college students are falling. Social injustice resulting from organizational decisions and actions causes profound and unnecessary human suffering, and research to understand antecedents to these decisions and actions lacks attention. Empathy represents a potential tool and critical skill for organizational decision-makers, with empirical evidence linking empathy to moral recognition of ethical situations and greater breadth of understanding of stakeholder impact and improved (...) financial success. This study explores the potential relationship between empathy and social justice, using a multifaceted operationalization of social justice, which includes management actions and social sympathies. Results broadly support the positive empathy and social justice relationship and suggest higher education interventions to develop empathy in college business students. (shrink)

Given its non-invasive nature, there is increasing interest in the use of transcutaneous vagus nerve stimulation across basic, translational and clinical research. Contemporaneously, tVNS can be achieved by stimulating either the auricular branch or the cervical bundle of the vagus nerve, referred to as transcutaneous auricular vagus nerve stimulation and transcutaneous cervical VNS, respectively. In order to advance the field in a systematic manner, studies using these technologies need to adequately report sufficient methodological detail to enable comparison of results between (...) studies, replication of studies, as well as enhancing study participant safety. We systematically reviewed the existing tVNS literature to evaluate current reporting practices. Based on this review, and consensus among participating authors, we propose a set of minimal reporting items to guide future tVNS studies. The suggested items address specific technical aspects of the device and stimulation parameters. We also cover general recommendations including inclusion and exclusion criteria for participants, outcome parameters and the detailed reporting of side effects. Furthermore, we review strategies used to identify the optimal stimulation parameters for a given research setting and summarize ongoing developments in animal research with potential implications for the application of tVNS in humans. Finally, we discuss the potential of tVNS in future research as well as the associated challenges across several disciplines in research and clinical practice. (shrink)

Given its non-invasive nature, there is increasing interest in the use of transcutaneous vagus nerve stimulation across basic, translational and clinical research. Contemporaneously, tVNS can be achieved by stimulating either the auricular branch or the cervical bundle of the vagus nerve, referred to as transcutaneous auricular vagus nerve stimulation and transcutaneous cervical VNS, respectively. In order to advance the field in a systematic manner, studies using these technologies need to adequately report sufficient methodological detail to enable comparison of results between (...) studies, replication of studies, as well as enhancing study participant safety. We systematically reviewed the existing tVNS literature to evaluate current reporting practices. Based on this review, and consensus among participating authors, we propose a set of minimal reporting items to guide future tVNS studies. The suggested items address specific technical aspects of the device and stimulation parameters. We also cover general recommendations including inclusion and exclusion criteria for participants, outcome parameters and the detailed reporting of side effects. Furthermore, we review strategies used to identify the optimal stimulation parameters for a given research setting and summarize ongoing developments in animal research with potential implications for the application of tVNS in humans. Finally, we discuss the potential of tVNS in future research as well as the associated challenges across several disciplines in research and clinical practice. (shrink)

Anselm: I agreed that Pegasus is a flying horse according to the stories people tell, the paintings painters paint and so on . That is, Pegasus is a flying horse in the understanding of storytellers, their readers and the artists who depict Pegasus. You asked whether flying is not an unmediated causal power . Well, it could be an unmediated causal power if you or I had it, but not if a being with only mediated powers had it. And so (...) poor Pegasus, a being whose powers are only those given him by storytellers and artists, has only the mediated power of flying that they have given him. He flies in the thoughts and depictions of beings with unmediated powers. Still, Pegasus has not only the mediated power to fly but also the mediated power to entertain us, and perhaps even inspire us. Fool: But people could tell stories about you, too, about how you sprouted wings and flew onto the roof of Canterbury Cathedral. Anselm: Alas, if it were only in stories that I could do that, then flying would not be an unmediated causal power of mine. I would still have unmediated causal powers all right, and so would be greater than Pegasus. But flying is not one of my unmediated causal powers. However, something than which nothing greater can be conceived would, and does, as I have proved in my Proslogion, have unmediated causal powers – indeed, much greater unmediated causal powers than any poor mortals like you and me.1 •↵1 For …. (shrink)

Light adaptation is modulated almost exclusively by changes in intracellular Ca2+ concentration, and other Ca2+-independent mechanisms are likely to play only a minor role. Changes in Ca2+i may be not only necessary for light adaptation to take place but sufficient to cause it.

Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Theologian's Doubts:Natural Philosophy and the Skeptical Games of GhazālīLeor HaleviIn the history of skeptical thought, which normally leaps from the Pyrrhonists to the rediscovery of Sextus Empiricus in the sixteenth century, Abū Ḥāmid Muḥammad al-Ghazālī (1058-1111) figures as a medieval curiosity. Skeptical enough to merit passing acknowledgment, he has proven too baffling to be treated fully alongside pagan, atheist, or materialist philosophers. As a theologian defending certain Muslim (...) dogmas, Ghazālī has not met what historians consider the mark of the true skeptic, a mind doubting the possibility of all systems of knowledge. But what is fascinating about him is that he brought into practical operation the tools of what I call "functional skepticism."1He denied the claims to truth of Aristotelian physics—whose basis he showed to rest on groundless belief—then turned and argued for the possibility of the Resurrection tooth and nail. The scholarly debate on The Incoherence of the Philosophers (Tahāfut al-falāsifa) has concentrated on the extent to which Ghazālī qua Ashcarite theologian was seduced into Aristotelian philosophy despite himself.2 In my view this debate has been misguided in the attempt to distill the [End Page 19] essence of Ghazālī from the book's eclectic theology; I will argue for a different view of Ghazālī on the basis of a close reading of key passages. In the unusual sections where Ghazālī applies Aristotelian language to a world not following the ordinary laws of physics, some have found Ghazālī slipping, unconsciously perhaps, into an Aristotelian frame of mind. I will show that, as a skeptical theologian with a dialogic imagination, he was rather deconstructing Aristotelian discourse while playing a Wittgensteinian sort of language game.Natural Philosopher or Speculative Theologian?The disagreement about the extent to which philosophy infected Ghazālī is ancient. Ghazālī might have studied philosophy only in order to refute it. He himself defended his philosophizing with the claim that one cannot deconstruct a system of thought until one has understood it so deeply as to elaborate upon its fundamental principles.3 His Maqāṣid al-falāsifa was in fact received, especially in trans-Pyrenean Europe, as a philosopher's genuine summary of the object of philosophy.4 The book strikes me as suspiciously creative in its representation of philosophical discourse, but it appears in any case as an expert and surprisingly unbiased treatment.5 Arabic readers knew that Ghazālī had also written a polemical treatise against philosophy, Tahāfut al-falāsifa, but they still wondered about his engagement with the ideas he challenged. Abū Bakr Ibn al-cArabī, for example, commented that Ghazālī had been unable to extricate himself from philosophy.6 Other philosophers pondered whether or not he had been a closeted member of their charmed circle and sought in his writings traces of esoteric philosophy.7Averroës's own sober sense of distance between philosophy and theology was partially a reaction to what he perceived as Ghazālī's dangerous and carefree mixture of the two sciences.8 He attacked Ghazālī's book in The Incoherence [End Page 20] of the Incoherence to restore philosophy's sense of purity, an aim he sought to accomplish by separating religious concerns from the philosopher's field of inquiry.9 Ironically, such a separation is precisely what Ghazālī might have wished to provoke by crisscrossing and blurring the line between religion and philosophy.The modern debate on chapter 17 of Tahāfut al-falāsifa has concentrated on defining Ghazālī as either a natural philosopher or an occasionalist theologian. In his defense of the possibility of miracles Ghazālī presented two theories of causation, one denying the logical basis of Aristotelian notions of natural causality, and the other more or less adopting these notions. Jointly, the two theories have seemed incompatible, and for this reason scholars have attempted to sort Ghazālī out of the apparent confusion. In 1978 L. E. Goodman argued persuasively that Ghazālī exploited rather than denied the philosophers' ideas of causality. In two articles Michael Marmura challenged Goodman, contending... (shrink)

Physical activity, and likely the motivation for it, varies throughout the day. The aim of this investigation was to create a short assessment (CRAVE: Cravings for Rest and Volitional Energy Expenditure) to measure motivation states (wants, desires, urges) for physical activity and sedentary behaviors. Five studies were conducted to develop and evaluate the construct validity and reliability of the scale, with 1,035 participants completing the scale a total of 1,697 times. In Study 1, 402 university students completed a questionnaire inquiring (...) about the want or desire to perform behaviors “at the present moment (right now).” Items related to physical activity (e.g., “move my body”) and sedentary behaviors (e.g., “do nothing active”). An exploratory structural equation model (ESEM) revealed that 10 items should be retained, loading onto two factors (5 each for Move and Rest). In Study 2, an independent sample (n= 444) confirmed these results and found that Move and Rest desires were associated with stage-of-change for exercise behavior. In Study 3, 127 community-residing participants completed the CRAVE at 6-month intervals over two years- two times each session. Across-session interclass correlations (ICC) for Move (ICC = 0.72–0.95) and Rest (ICC = 0.69–0.88) were higher than when they were measured across 24-months (Move: ICC = 0.53; Rest: ICC = 0.49), indicating wants/desires have state-like qualities. In Study 4, a maximal treadmill test was completed by 21 university students. The CRAVE was completed immediately pre and post. Move desires decreased 26% and Rest increased 74%. Changes in Move and Rest desires were moderately associated with changes in perceived physical fatigue and energy. In Study 5, 41 university students sat quietly during a 50-min lecture. They completed the CRAVE at 3 time points. Move increased 19.6% and Rest decreased 16.7%. Small correlations were detected between move and both perceived energy and tiredness, but not calmness or tension. In conclusion, the CRAVE scale has good psychometric properties. These data also support tenets of the WANT model of motivation states for movement and rest (Stults-Kolehmainen et al., 2020a). Future studies need to explore how desires to move/rest relate to dynamic changes in physical activity and sedentarism. (shrink)

Reductive metaethical views have ethical implications that are frequently inconsistent with our settled ethical intuitions and favored ethical theories. This makes theory choice in metaethics difficult. When we are assessing reductive views, what sort of weight should we accord to their counterintuitive ethical implications? How should we weigh intensional adequacy and explanatory power against apparent extensional inadequacy? I argue that we currently assign too much weight to extensional worries in our metaethical theorizing: We should be willing to tolerate even a (...) great many counterintuitive ethical implications for the sake of a compelling explanation of our ethical practices. Especially when it comes to theorizing about reasons for action, extensional worries should take a back seat to intensional adequacy and explanatory power. My case for this claim beings with a familiar story about the origins of our moral concepts drawn from the work of G. E. M. Anscombe and Alisdair MacIntyre and proceeds via an observation about the nature of practical reasoning. (shrink)

Philosophical debate about the meaning of normative terms has long been pulled in two directions by the apparently competing ideas: (i) ‘ought’s do not describe what is actually the case but rather prescribe possible action, thought, or feeling, (ii) all declarative sentences deserve the same general semantic treatment, e.g. in terms of compositionally specified truth conditions. In this paper, I pursue resolution of this tension by rehearsing the case for a relatively standard truth-conditionalist semantics for ‘ought’ conceived as a necessity (...) modal and proposing a revision to it motivated by the distinctively prescriptive character of some deontic modals. In my view, this puts pressure on a popular conception of one of the core debates of metanormative theory between realists and antirealists. To make good on this claim, I go on to explore two very general ways we might interpret the results of compositional semantics—“representationalism” and “inferentialism”—in order to argue that, contrary to what is generally assumed, both can capture the special prescriptivity of ‘ought’ and both can countenance compositionally specified and informative truth-conditions for ought-sentences. Hence, my main thesis is that the deciding factor between them should not be which of ideas (i) and (ii) we are more impressed by but rather what we think of the relative merits of how representationalism and inferentialism respect these ideas. I’m inclined to favor an antirealist form of inferentialism, but the task I’ve set myself here is mainly to articulate the view in the context of metanormative theory and the semantics of deontic modals rather than try to defend it fully. To this purpose, towards the end I also briefly compare and contrast inferentialism with a third “ideationalist” metasemantic view, which may be an attractive home for some sophisticated versions of metanormative expressivism. Depending on how expressivism is worked out, it may be completely compatible with and so perhaps usefully combined with inferentialism or it may offer a competing way to respect ideas (i) and (ii). (shrink)

Apologies have long been considered an important social action in many languages for dealing with frictions of everyday interaction and restoring interpersonal harmony in response to an offense. Although there has been an increasing amount of research on apologies in non-Western languages, little research involves children. Japan is an interesting case in which to examine apologies. In particular, Japan has been called a “culture of apology“ in the sense that speakers often `apologize' (ayamaru) in a wide range of communicative contexts. (...) This article examines children's socialization to a culture of apology as evidenced by a large corpus of audiovisual recordings made over the last decade in households, playgrounds, and a preschool in Japan. In particular, it examines ways Japanese caregivers (e.g. parents, preschool teachers) use the expressions Gomen ne and Gomen-nasai ([I'm/We're] sorry) when addressing third parties, including not only other people (e.g. children's peers) but also a range of entities in the surround (e.g. animals, supernatural objects, objects in the environment such as a stone), and ways they prompt children to say these expressions to such third parties. This analysis suggests that apology situations are an important site through which children are socialized to empathy and relationships in the social world. It also examines ways children use these expressions when addressing peers and inanimate objects, and ways they prompt others including peers and even on occasion adults to say them. These findings suggest that while children deploy strategies in ways that reflect the socialization process, they also deploy them in ways that construct this process in creative ways. (shrink)

Here, I examine the epistemic relation between beliefs about the nature of sexual orientation (e.g., beliefs concerning whether orientation is dispositional) and beliefs about the taxonomy of orientation categories (e.g., beliefs concerning whether polyamorous is an orientation category). Current philosophical research gives epistemic priority to the former class of beliefs, such that beliefs about the taxonomy of orientation categories tend to be jettisoned or revised in cases of conflict with beliefs about the nature of sexual orientation. Yet, considering the influence (...) of ideology on beliefs about socially significant phenomena, I argue for an epistemic reversal. (shrink)

In his theoretical philosophy, Immanuel Kant argues that experience comes from two sources that are radically different but equally necessary: the rule-governed activity of thinking and the givenness of sensations. He supposes that both could be traced to some common root but concludes that whatever it is, is in principle unknowable. Kant's idealist successors, J.G. Fichte and F.W.J. Schelling, each attempt to provide a unified account of experience by identifying the ultimate basis of subject and object—Fichte by referring to the (...) I's activity and Schelling by referring to the Absolute. Because we can know only appearances, an implication of Kant's transcendental inquiry, Fichte and Schelling have difficulty... (shrink)

Reasons are considerations that figure in sound reasoning. This is considered by many philosophers to be little more than a platitude. I argue that it actually has surprising and far-reaching metanormative implications. The view that reasons are linked to sound reasoning seems platitudinous only because we tend to assume that soundness is a normative property, in which case the view merely relates one normative phenomenon (reasons) to another (soundness). I argue that soundness is also a descriptive phenomenon, one we can (...) pick out with purely descriptive terms, and that the connection between normative reasons and sound reasoning therefore provides the basis for a reductive account of reasons. Like all proposed reductions, this one must confront some version of G. E. Moore’s open question argument. I argue that a reductive view rooted in the idea that reasons figure in sound reasoning is well-equipped to meet the open question challenge head on. (shrink)

Talk of different types of cells is commonplace in the biological sciences. We know a great deal, for example, about human muscle cells by studying the same type of cells in mice. Information about cell type is apparently largely projectible across species boundaries. But what defines cell type? Do cells come pre-packaged into different natural kinds? Philosophical attention to these questions has been extremely limited [see e.g., Wilson (Species: New Interdisciplinary Essays, pp 187–207, 1999; Genes and the Agents of Life, (...) 2005; Wilson et al. Philos Top 35(1/2):189–215, 2007)]. On the face of it, the problems we face in individuating cellular kinds resemble those biologists and philosophers of biology encountered in thinking about species: there are apparently many different (and interconnected) bases on which we might legitimately classify cells. We could, for example, focus on their developmental history (a sort of analogue to a species’ evolutionary history); or we might divide on the basis of certain structural features, functional role, location within larger systems, and so on. In this paper, I sketch an approach to cellular kinds inspired by Boyd’s Homeostatic Property Cluster Theory, applying some lessons from this application back to general questions about the nature of natural kinds. (shrink)

Several philosophers (e.g., Ehring (Nous (Detroit, Mich.) 30:461–480, 1996 ); Funkhouser (Nous (Detroit, Mich.) 40:548–569, 2006 ); Walter (Canadian Journal of Philosophy 37:217–244, 2007 ) have argued that there are metaphysical differences between the determinable-determinate relation and the realization relation between mental and physical properties. Others have challenged this claim (e.g., Wilson (Philosophical Studies, 2009 ). In this paper, I argue that there are indeed such differences and propose a “mechanistic” account of realization that elucidates why these differences hold. This (...) account of realization incorporates two distinct roles that mechanisms play in the realization of mental (and other special science) properties which are implicit, but undeveloped, in the literature—what I call “constitutive” and “integrative” mechanisms. I then use these two notions of mechanism to clarify some debates about the relations between realization, multiple realizability, and irreducibility. (shrink)

I claim that consciousness, just as thought or action, is only to be found at the personal level of explanation. Dennett's account is often taken to be at odds with this view, as it is seen as explicating consciousness in terms of sub-personal processes. Against this reading, and especially as it is developed by John McDowell, I argue that Dennett's work is best understood as maintaining a sharp personal/sub-personal distinction. To see this, however, we need to understand better what content (...) ascription at the sub-personal level actually means. When we do we can see how Dennett presents both a philosophical account of consciousness and informed empirical speculation on the nature of its sub-personal underpinnings. Consciousness is a product of certain capacities that are intelligible only at the personal level, capacities that are neither present at the sub-personal level of brain mechanism nor present in 'sub-persons', e.g. some, if not all, non-human animals. (shrink)

Assertion is a speech act that stands at the intersection of the philosophy of language and social epistemology. It is a phenomenon that bears on such wide-ranging topics as testimony, truth, meaning, knowledge and trust. It is thus no surprise that analytic philosophers have devoted innumerable pages to assertion, trying to give the norms that govern it, its role in the transmission of knowledge, and most importantly, what assertion is, or how assertion is to be defined. In this thesis I (...) attempt to show that all previous answers to the question “What is assertion?” are flawed. There are four major traditions in the literature: constitutive norm theories of assertion, accounts that treat assertion as the expression of speaker attitudes, accounts that treat assertion as a proposal to add some proposition to the common ground, and accounts that treat assertion as the taking of responsibility for some claim. Each tradition is explored here, the leading theories within the tradition developed, and then placed under scrutiny to demonstrate flaws within the positions surveyed. I follow the work of G.E. Moore and William P. Alston, whilst drawing on the work of Robert Brandom in order to give a new bipartite theory of assertion. I argue that assertion consists in the explicit presentation of a proposition, along with a taking of responsibility for that proposition. Taking Alston's explicit presentation condition and repairing it in order to deal with problems it faces, whilst combining it with Brandom's responsibility condition, provides, I believe, the best account of assertion. (shrink)

Assertion is a speech act that stands at the intersection of the philosophy of language and social epistemology. It is a phenomenon that bears on such wide-ranging topics as testimony, truth, meaning, knowledge and trust. It is thus no surprise that analytic philosophers have devoted innumerable pages to assertion, trying to give the norms that govern it, its role in the transmission of knowledge, and most importantly, what assertion is, or how assertion is to be defined. -/- In this thesis (...) I attempt to show that all previous answers to the question “What is assertion?” are flawed. There are four major traditions in the literature: constitutive norm theories of assertion, accounts that treat assertion as the expression of speaker attitudes, accounts that treat assertion as a proposal to add some proposition to the common ground, and accounts that treat assertion as the taking of responsibility for some claim. Each tradition is explored here, the leading theories within the tradition developed, and then placed under scrutiny to demonstrate flaws within the positions surveyed. -/- I follow the work of G.E. Moore and William P. Alston, whilst drawing on the work of Robert Brandom in order to give a new bipartite theory of assertion. I argue that assertion consists in the explicit presentation of a proposition, along with a taking of responsibility for that proposition. Taking Alston’s explicit presentation condition and repairing it in order to deal with problems it faces, whilst combining it with Brandom’s responsibility condition, provides, I believe, the best account of assertion. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Ius Gentium as Publicly Articulated Moral ScienceMatthew K. MinerdAmong the various types of law discussed in St. Thomas's theological "treatise on law"—questions 90–108 of Summa theologia [ST] I-II—the classification known as the "law of nations" (ius gentium) holds an ambiguous epistemological position. Marking a kind of halfway point between the natural law and civil law, it seems to straddle both domains. In fact, in a particularly important text dedicated (...) to this topic in the ST (I-II, q. 95, a. 4), Aquinas classes the ius gentium as being closely connected to the natural law, though in a way that is somewhat derivative, not as immediately flowing from human nature (especially in its animality) as does the natural law, but also not as marked by human contingency as is human civil law.As was recently discussed in a well-documented and insightful article by Barrett H. Turner in The Thomist, there have historically been two main lines of Thomist interpretation concerning the exact character of the "law of nations." Very broadly stated, what he refers to as the "Salamancan" line, indebted to Francisco de Vitoria, "interprets Thomas's doctrine of the ius gentium as a body of universal positive institutions (that is, specifications, determinationes) added to the natural law by agreement of the human race."1 [End Page 1043] This position, which would be common for several centuries among members of the Thomist school, would locate the law of nations essentially in the domain of nearly universally adopted customs and institutions, not strictly deduced from the natural law, but rather grounded on "the quasi-political authority of the entire human race, which promulgates the ius gentium by customs whose utility for attaining the ends of the natural law under a certain set of social conditions is easily recognized by rational creatures."2Turner calls the other line of thought "Maritain's Neo-Thomist Line,"3 an outlook that would be shared with various nuances by thinkers like Jean-Marie Aubert, Yves Simon, Marie-Michel Labourdette, John Finnis, and others. Setting aside my qualms about his appellation "neo-Thomist," which does more to obscure than to illumine (for it covers a host of Thomistic figures who have significantly different views on what constitutes "Thomism"), Turner does fairly lay out the major lines of Jacques Maritain's position, which is most directly articulated in Man and the State and La loi naturelle ou loi non-écrite.4 Basing himself on his particular view of knowledge of the natural law through connaturality,5 Maritain contrasted this sort of moral cognition with that which develops in the line of conceptual articulation, thus having a different "gnoseological" character from our knowledge of the natural law, while nonetheless still sharing the same "ontological" foundation. Such conceptually articulated law would be the ius gentium.Rather than add my voice to the dialectic of the various thinkers arrayed by Turner into the two aforementioned camps, I would like to propose a slightly different approach to the "moral epistemology of the law of nations," though one that I believe lies in line with the best aspects of Maritain's approach. Continuing a series of reflections that I have undertaken [End Page 1044] concerning moral epistemology during the past few years,6 I propose that it is most helpful to consider the "law of nations" as being a form of reasoning pertaining to what Scholastic vocabulary would refer to as "moral science,"7 namely discursive philosophical reasoning concerning the essences, properties, effects, and various other essential relationships that belong to a human acts, morally considered (the principal subject of moral philosophy), along with other subjects that are studied in relation to this principal subject (e.g., the principles of human acts, most particularly, the structure of human acts and the moral virtues). Moral science is the activity of reasoning that can be undertaken by knowing agents living together in community, seeking to discursively articulate and explain the moral truth that forms the essential basis for the contingent determinations that will then be codified in particular civil laws, the latter of which are not concerned with questions like "what are the ultimate foundations for property... (shrink)

Market structures have come to dominate every area of our society, and market logic—in the form of rational choice theory, the law and economics movement, and the like—has equally dominated our thinking about society. In this thesis, I will examine one critique of this state of affairs: that offered by G.W.F. Hegel. I compare Hegel’s critique of the market to the similar critique of modern communitarians like Charles Taylor and Michael Sandel, and argue that Hegel’s distinctive conception of freedom allows (...) him to capture what is right about the modern communitarian view while avoiding most of the common criticisms. (shrink)

I claim that consciousness, just as thought or action, is only to be found at the personal level of explanation. Dennett's account is often taken to be at odds with this view, as it is seen as explicating consciousness in terms of sub‐personal processes. Against this reading, and especially as it is developed by John McDowell, I argue that Dennett's work is best understood as maintaining a sharp personal/sub‐personal distinction. To see this, however, we need to understand better what content (...) ascription at the sub‐personal level actually means. When we do we can see how Dennett presents both a philosophical account of consciousness and informed empirical speculation on the nature of its sub‐personal underpinnings. Consciousness is a product of certain capacities that are intelligible only at the personal level, capacities that are neither present at the sub‐personal level of brain mechanism nor present in ‘sub‐persons’, e.g. some, if not all, non‐human animals. (shrink)

© Copyright 2015, Mary Ann Liebert, Inc..Signal transducer and activator of transcription factor 3 is hyperactivated in head and neck squamous cell carcinomas. Cumulative evidence indicates that IL-6 production by HNSCC cells and/or stromal cells in the tumor microenvironment activates STAT3 and contributes to tumor progression and drug resistance. A library of 94,491 compounds from the Molecular Library Screening Center Network was screened for the ability to inhibit interleukin-6 -induced pSTAT3 activation. For contractual reasons, the primary high-content screening campaign was (...) conducted over several months in 3 distinct phases; 1,068 primary HCS actives remained after cytotoxic or fluorescent outliers were eliminated. One thousand one hundred eighty-seven compounds were cherry-picked for confirmation; actives identified in the primary HCS and compounds selected by a structural similarity search of the remaining MLSCN library using hits identified in phases I and II of the screen. Actives were confirmed in pSTAT3 IC50 assays, and an IFNγ-induced pSTAT1 activation assay was used to prioritize selective inhibitors of STAT3 activation that would not inhibit STAT1 tumor suppressor functions. Two hundred three concentration-dependent inhibitors of IL-6-induced pSTAT3 activation were identified and 89 of these also produced IC50s against IFN-γ-induced pSTAT1 activation. Forty-nine compounds met our hit criteria: they reproducibly inhibited IL-6-induced pSTAT3 activation by ≥70% at 20 μM; their pSTAT3 activation IC50s were ≤25 μM; they were ≥2-fold selective for pSTAT3 inhibition over pSTAT1 inhibition; a cross target query of PubChem indicated that they were not biologically promiscuous; and they were ≥90% pure. Twenty-six chemically tractable hits that passed filters for nuisance compounds and had acceptable drug-like and ADME-Tox properties by computational evaluation were purchased for characterization. The hit structures were distributed among 5 clusters and 8 singletons. Twenty-four compounds inhibited IL-6-induced pSTAT3 activation with IC50s ≤20 μM and 13 were ≥3-fold selective versus inhibition of pSTAT1 activation. Eighteen hits inhibited the growth of HNSCC cell lines with average IC50s ≤ 20 μM. Four chemical series were progressed into lead optimization: the guanidinoquinazolines, the triazolothiadiazines, the amino alcohols, and an oxazole-piperazine singleton. (shrink)

It has become quite common for people to develop `personal'' relationships nowadays, exclusively via extensive correspondence across the Net. Friendships, even romantic love relationships, are apparently, flourishing. But what kind of relations really are possible in this way? In this paper, we focus on the case of close friendship. There are various important markers that identify a relationship as one of close friendship. One will have, for instance, strong affection for the other, a disposition to act for their well-being and (...) a desire for shared experiences. Now obviously, while all these features of friendship can gain some expression through extensive correspondence on the Net, such expression is necessarily limited –you cannot, e.g., physically embrace the other, or go on a picnic together. The issue we want to address here however, is whether there might be distinctive and important influences on the structure of interaction undertaken on the Net, that affect the kind of identity ``Net-friends'''' can develop in relation to one another. In the normal case, one develops a close friendship, and in doing so, one''s identity, in part, is shaped by the friendship. To some extent, through extensive shared experience, one comes to see aspects of the world (and of oneself) through the eyes of one''s friend and so, in part, one''s identity develops in an importantly relational way, i.e., as the product of one''s relation with the close friend. In our view, however, on account of the limits of, and/or the kind of, shared contact and experience one can have with another via correspondence on the Net, there are significant structural barriers to developing the sort of relational identity that is a feature of close friendship. In arguing our case here, and by using the case of Net ``friendship'''' as our foil, we aim to shed light on the nature and importance of certain sorts of self-expression and relational interaction found in close friendship. (shrink)

Conditional information can be equally asserted in the forms if p, then q (e.g., ?if I am ill, I will miss work tomorrow?) and q, if p (e.g., ?I will miss work tomorrow, if I am ill?). While this type of clause order manipulation has previously been found to have no influence on the ultimate conclusions participants draw from conditional rules, we used self-paced reading to examine how it affects the real time incremental processing of everyday conditional statements. Experiment 1 (...) revealed that clause order interacts with presuppositional congruency as readers hypothetically represent counterfactual statements. When if p, then q counterfactuals contained a presupposition that was incongruent with prior context, these statements took longer to read than when the presupposition was congruent, but for q, if p conditionals there was no such congruency effect. Experiment 2 revealed that reading times were influenced by the subjective probability of an indicative conditional regardless of clause order, with a penalty observed for low-probability statements relative to high-probability statements in both conditional clause orders. These data reveal a dissociation whereby clause order mediates the effect of suppositional congruency on reading times, but does not mediate the effect of subjective probability. (shrink)

In this paper, we use antecedent-final conditionals to formulate two problems for parsing-based theories of presupposition projection and triviality of the kind given in Schlenker 2009. We show that, when it comes to antecedent-final conditionals, parsing-based theories predict filtering of presuppositions where there is in fact projection, and triviality judgments for sentences which are in fact felicitous. More concretely, these theories predict that presuppositions triggered in the antecedent of antecedent-final conditionals will be filtered (i.e. will not project) if the negation (...) of the consequent entails the presupposition. But this is wrong: John isn’t in Paris, if he regrets being in France intuitively presupposes that John is in France, contrary to this prediction. Likewise, parsing-based approaches to triviality predict that material entailed by the negation of the consequent will be redundant in the antecedent of the conditional; but John isn’t in Paris, if he’s in France and Mary is with him is intuitively felicitous, contrary to these predictions. Importantly, given that the trigger appears in sentence-final position, both incremental (left-to-right) and symmetric versions of such theories make the same predictions. These data constitute a challenge to the idea that presupposition projection and triviality should be computed on the basis of parsing. This issue is important because it relates to the more general question as to whether presupposition and triviality calculation should be thought of as a pragmatic post-compositional phenomenon or as part of compositional semantics (as in the more traditional dynamic approaches). We discuss a solution which allows us to maintain the parsing-based pragmatic approach; it is based on an analysis of conditionals which incorporates a presupposition that their antecedent is compatible with the context, together with a modification to Schlenker’s (2009) algorithm for calculating local contexts so that it takes into account presupposed material. As we will discuss, this solution works within a framework broadly similar to that of Schlenker’s (2009), but it doesn’t extend in an obvious way to other parsing-based accounts (e.g. parsing-based trivalent approaches). We conclude that a parsing-based theory can be maintained, but only if we adopt a substantial change of perspective on the framework. (shrink)

© 2015, Springer-Verlag Berlin Heidelberg.Genetic studies have identified single nucleotide polymorphisms associated with the risk of prostate cancer. It remains unclear whether such genetic variants are associated with disease aggressiveness. The NCI-SPORE Genetics Working Group retrospectively collected clinicopathologic information and genotype data for 36 SNPs which at the time had been validated to be associated with PC risk from 25,674 cases with PC. Cases were grouped according to race, Gleason score and aggressiveness. Statistical analyses were used to compare the frequency (...) of the SNPs between different disease cohorts. After adjusting for multiple testing, only PC-risk SNP rs2735839 was significantly and inversely associated with aggressive and high-grade disease in European men. Similar associations with aggressive and high-grade disease were documented in African-American subjects. The G allele of rs2735839 was associated with disease aggressiveness even at low PSA levels in both European and African-American men. Our results provide further support that a PC-risk SNP rs2735839 near the KLK3 gene on chromosome 19q13 may be associated with aggressive and high-grade PC. Future prospectively designed, case-case GWAS are needed to identify additional SNPs associated with PC aggressiveness. (shrink)

We consider the class of pointed varieties of algebras having a lattice term reduct and we show that each such variety gives rise in a natural way, and according to a regular pattern, to at least three interesting logics. Although the mentioned class includes several logically and algebraically significant examples (e.g. Boolean algebras, MV algebras, Boolean algebras with operators, residuated lattices and their subvarieties, algebras from quantum logic or from depth relevant logic), we consider here in greater detail Abelian ℓ-groups, (...) where such logics respectively correspond to: i) Meyer and Slaney’s Abelian logic [31]; ii) Galli et al.’s logic of equilibrium [21]; iii) a new logic of “preservation of truth degrees”. (shrink)

Addiction is a common condition affecting millions of people worldwide of which only a small proportion receives treatment. The development and use of healthcare services is influenced by how addiction is understood (e.g., a condition to treat, a shameful condition to stigmatize), notably with respect to how volition is impacted (e.g., addiction as a choice or a disease beyond one’s control). Through semi-structured qualitative interviews, we explore the implicit views and understandings of addiction and volition across three stakeholder groups: people (...) with lived experience of addiction, clinicians with experience treating addiction, and members of the public without lived experience of addiction. We notably examine whether three paradigms, i.e., three philosophical sets of understandings about the nature of reality and knowledge (realism, relativism, pragmatism) reflect how stakeholders envision addiction and volition in the context of addiction. The use of these paradigms allows for the characterization of different stances on addiction and volition and an assessment of the coherence of beliefs about these matters. Our findings demonstrate that few participants relied on a single epistemic paradigm when describing their views. Furthermore, there were notable differences in understandings of volition between the clinician group, who were more oriented toward pragmatism, and people with lived experience of addiction, who were less oriented toward realism. Despite its limitations, our study suggests that a greater appreciation for the complexity of views held by different stakeholders about addiction and volition could help critically assess the search for coherence expressed in academic and policy debates. (shrink)

If there is a “basic structure objection” to G.A. Cohen’s incentive critique of Rawls, then there is also a BSO to claims that private racial discrimination thwarts social justice by reducing the opportunity of its targets. In this paper, I take up the debate about the site or purview of justice and discuss it with reference to the case of race. I argue that the dispute about the site of justice has been wrongly understood as a dispute about the substantive (...) requirements of justice instead of as a dispute about where it is appropriate to apply considerations of justice. (shrink)

In Sect. 1 of this chapter, Matthew McGrath examines Sosa's work on the nature of truth. Sosa's chief purpose is to determine what sort of theory of truth is appropriate for truth-centered epistemology -- an epistemology that takes truth to be the goal of inquiry and which explains key epistemic notions in terms of truth. While Sosa refutes arguments from Putnam and Davidson against the correspondence theory, he is hesitant to endorse it because he doubts we have a clear (...) enough grasp of what correspondence amounts to and what the correspondents are. A truth-centered epistemologist, however, is free to work with minimalism about truth and Moorean primitivism. Part of Sosa's case for primitivism, and against minimalism, involves a comparison with Moore's account of goodness. Here McGrath notes an important dissimilarity between the two (i.e., susceptibility to open-question arguments) and suggests that this may be reason to prefer minimalism to primitivism. -/- In Sect. 2, Jeremy Fantl discusses Sosa's work on the role of truth in epistemology. Sosa seems to be motivated by a dilemma facing any account of that role on which true belief is the sole fundamental epistemic value. On the one hand, we want an account of the role of truth in epistemology to explain why we epistemically evaluate beliefs and guide our intellectual lives in the way we do. On the other hand, it should not come out that we have any sort of epistemic obligation to form beliefs about completely boring or trivial matters (e.g., about the first phone number listed on page 356 of the phone book). Sosa's attempt to resolve the dilemma is to, first of all, adopt something like a pluralism about epistemic value and, second of all, move the primary locus of epistemic evaluation from beliefs to faculties. The second part of this chapter investigates the intricacies of these maneuvers. (shrink)

Plato and Aristotle thought that philosophy begins in the perplexed recognition that there are significant puzzles one does not know how to deal with. Some such puzzles can be expressed in questions of the form, ‘How is it possible that p?’, e.g., ‘How is it possible that the world had an absolute beginning?’ I discuss an example of young children asking that last question and go on, with further examples, to make a plea for cultivating such questions as an educational (...) objective, whether the perplexity-expressing questions themselves be scientific, philosophical, or both. (shrink)

BackgroundEthics review is the process of assessing the ethics of research involving humans. The Ethics Review Committee (ERC) is the key oversight mechanism designated to ensure ethics review. Whether or not this governance mechanism is still fit for purpose in the data-driven research context remains a debated issue among research ethics experts.Main textIn this article, we seek to address this issue in a twofold manner. First, we review the strengths and weaknesses of ERCs in ensuring ethical oversight. Second, we map (...) these strengths and weaknesses onto specific challenges raised by big data research. We distinguish two categories of potential weakness. The first category concerns persistent weaknesses, i.e., those which are not specific to big data research, but may be exacerbated by it. The second category concerns novel weaknesses, i.e., those which are created by and inherent to big data projects. Within this second category, we further distinguish between purview weaknesses related to the ERC’s scope (e.g., how big data projects may evade ERC review) and functional weaknesses, related to the ERC’s way of operating. Based on this analysis, we propose reforms aimed at improving the oversight capacity of ERCs in the era of big data science.ConclusionsWe believe the oversight mechanism could benefit from these reforms because they will help to overcome data-intensive research challenges and consequently benefit research at large. (shrink)

This paper responds to a previous paper by Gary Matthews and Lynne Rudder Baker. Their paper, in turn, was a response to my reply to an even earlier paper of theirs. (The relevant bibliographical details are in this paper.) They claim to have a new, improved, simple ontological argument. I argue that the new, simple ontological argument is not, in any way, improved.

In August 2021, Froese et al. published survey data collected from 2,543 respondents on their subjective experiences living under imposed social distancing measures during COVID-19 (1). The questionnaire was issued to respondents in the UK, Japan, and Mexico. By combining the authors’ expertise in phenomenological philosophy, phenomenological psychopathology, and enactive cognitive science, the questions were carefully phrased to prompt reports that would be useful to phenomenological investigation and theorizing (2–4). These questions reflected the various author’s research interests (e.g., technology, grief, (...) time). Between April 7th and July 31st, 2021, a second questionnaire with the same question set was issued to respondents of the original who had agreed to do a follow-up. This was intended to capture subjective reports of life under social distancing measures a year after the initial survey. By this time–depending on their country of residence and health status–respondents had potentially lived with repeated and prolonged lockdowns and a variety of other restrictions on their social lives. When taken together, Survey I and Survey II provide a cross-cultural and longitudinal dataset that allows for analysis of longer-term impacts of imposed social distancing measures on people’s experiences. For researchers working in diverse disciplines, this dataset offers a rich resource that reflects people’s reactions to the imposition of different social restrictions in different countries and over different time periods. (shrink)

ABSTRACT This essay argues for the emergence of a cultural and epistemological divide between amateur savants and members of the Royal Academy of the Sciences in late Old Regime and revolutionary France and suggests that the amateur ideal rose in significance even as intellectual activity came to be increasingly centralized in the postrevolutionary era. At the crux of the tensions between the amateur ideal and the professionalizing reality in the immediate postrevolutionary period stood Aubin-Louis Millin and his journal, the Magasin (...) Encyclopédique. The essay examines, in particular, the revival in the pages of the Magasin Encyclopédique of interest in Nicolas-Claude Fabri de Peiresc, the seventeenth-century icon of an amateur ideal in which investigations in the natural sciences and scholarship were private, decentralized, often provincial activities. Although the sciences in the revolutionary and Napoleonic eras were often perceived as forward looking and dismissive of the past, this essay finds that a sentimental and nostalgic attachment to the past—to a myth of Peiresc—continued to play an important role in the identity of postrevolutionary men of letters. (shrink)

This book challenges common historical misperceptions of both the history of the sciences in early modern France and the history of the French Enlightenment. Tracing the complex historical relationship between them, this reinterpretation critiques the view that the sciences were always politically neutral and that the philosophes were proto-republican. By reexamining the moral, political, and social ideas of those who defended the ascendency of the sciences, this book demonstrates the evolution of political views, in particular with the marquis de Condorcet, (...) from a commitment to absolute monarchy to revolutionary republicanism. (shrink)

Background: Studies have found that children with Autism Spectrum Disorder (ASD) are more likely to make errors in appropriately producing referring expressions (‘the dog’ vs. ‘the black dog’) than are controls but comprehend them with equal facility. We tested whether this anomaly arises because comprehension studies have focused on manipulating perspective-taking at a ‘generic speaker’ level. Method: We compared 24 autistic eight- to eleven-year-olds with 24 well-matched neuro-typical controls. Children interpreted requests (e.g. ‘Can I have that ball?’) in contexts which (...) would be ambiguous (i.e. because the child can see two balls) if perspective-taking were not utilized. In the interlocutor-specific perspective-taking condition, the target was the particular object which was new for the speaker. Children needed to take into account what the speaker had played with before and the fact that they were now expressing excitement about something new. In two control ‘speaker-generic’ conditions we tested children’s ability to take the visual perspective of the speaker (where any speaker who stood behind a particular barrier would have the same perspective). Results: The autistic group were significantly less likely to select the target and significantly more likely to request clarification in the ‘interlocutor-specific’ condition. Performance in the ‘interlocutor-generic’ (visual) perspective taking conditions did not differ between groups. Conclusion: Autistic children, even those who are not intellectually-impaired, tend to have more difficulty than neuro-typical peers in comprehending referring expressions when this requires understanding that people comment on what is new for them. (shrink)

Although hailing from cognate analytical schools, the contributors to Hedwig te Molder and Jonathan Potter’s edited volume Conversation and Cognition hold a remarkable diversity of views on the nature of “mental states” and their import for the purposes of analyzing naturally occurring interaction. I offer a critical analysis of some of the contributors’ discussions of cognition in social interaction in an effort to clarify some obstinate issues with respect to the meanings of words in our cognitive vocabulary (e.g. “thought” and (...) “realization”) and their identification in analyses of conversation. (shrink)

Henüz çok az çalışılmış veba risaleleri on dördüncü yüzyılın ortasındaki Kara Ölüm kıyametinden sonra yüzyıllarca tekrarlayan salgınlarla Batı Avrasya’yı kasıp kavuran kültürel dönüşümlere tanıklık eder. Bu türe Osmanlı katkıları, emperyal-bilimsel erken modernitenin ortaya çıkışını izlememize olanak sağlaması açısından örneklik teşkil eder. Bu makale bilinen en kapsamlı ve yenilikçi İslami veba risalesini, Taşköprîzâde Ahmed’in (ö.1561) Risâletü’ş-Şifâ’sını sunmaktadır. Bu eserde ünlü Osmanlı hezarfeni, hem dinî hem rasyonel argümanlar takdim ederek okült bilimin vebayı önlemede ve tedavi etmede en deneysel yöntem olduğuna dair çok (...) güçlü bir argüman oluşturur. Bu amaçla, eserin teorik ilk yarısını tevekkülü tesebbübe veya kör inancı “bilimsel yöntem”e tercih eden kaderci âlimlerin ve sûfîlerin eleştirisine ayırır; uygulamaya dair olan ikinci yarı ise yaşadığı dönemin tıbbi olarak en etkili bilimsel disiplini olduğunu düşündüğü, genel olarak Batı erken modernitesinin “kozmolojik tahayyül”ünü kapsayan, dünyanın pek çok düşünür ve fail tarafından matematiksel ve dolayısıyla sihirli bir şekilde izlenebilen bir metin olarak görüldüğü Yeni Pisagorcu bir bilim olan harfîliğe (ilm-i hurûf) ayrılmıştır. Okült bilimden hoşnutsuzluğumuza rağmen, Taşköprîzâde burada bir başka erken modern deneyimci olarak adlandırılmalıdır. (shrink)

The use of drones (or unmanned aerial vehicles, UVAs) in humanitarian action has emerged rapidly in the last decade and continues to expand. These so-called ‘humanitarian drones’ represent the first wave of robotics applied in the humanitarian and development contexts, providing critical information through mapping of crisis-affected areas and timely delivery of aid supplies to populations in need. Alongside these emergent uses of drones in the aid sector, debates have arisen about potential risks and challenges, presenting diverse perspectives on the (...) ethical, legal, and social implications of humanitarian drones. Guided by the methodology introduced by Arksey and O’Malley, this scoping review offers an assessment of the ethical considerations discussed in the academic and gray literature based on a screening of 1,188 articles, from which we selected and analyzed 47 articles. In particular, we used a hybrid approach of qualitative content analysis, along with quantitative landscape mapping, to inductively develop a typology of ethical considerations associated with humanitarian drones. The results yielded 11 key areas of concern: (1) minimizing harm, (2) maximizing welfare, (3) substantive justice, (4) procedural justice, (5) respect for individuals, (6) respect for communities, (7) regulatory gaps, (8) regulatory dysfunction, (9) perceptions of humanitarian aid and organizations, (10) relations between humanitarian organizations and industry, and (11) the identity of humanitarian aid providers and organizations. Our findings illuminate topics that have been the focus of extensive attention (such as minimizing risks of harm and protecting privacy), traces the evolution of this discussion over time (i.e., an initial focus on mapping drones and the distinction of humanitarian from military use, toward the ethics of cargo drones carrying healthcare supplies and samples), and points to areas that have received less consideration (e.g., whether sustainability and shared benefits will be compromised if private companies’ interest in humanitarian drones wanes once new markets open up). The review can thus help to situate and guide further analysis of drone use in humanitarian settings. (shrink)